How many macros and standard cell were there in your block?

Answer to this question is purely on the design specific, bu there are blocks without macros also, which is called purely standard cell cells blocks. As number of macros increased, analysis in the floor plan also increases, below are some checks which you have to do while handling large number of macro

1. Legalization of macros

2. connectivity of macros to standard cells, other macro and ports, ignoring of this point may cause the congestion and timing violation

3. while arranging the macros in floorplan consider macro to macro communication also

4. always keep some channel between the macro, in later stages this will help in hold buffering,